International Angelman Day – Global
15th February Annually
Phase 3 Aspire trial of gene therapy GTX-102 doses 1st patient
New trial, Aurora, to test GTX-102 in other Angelman genotypes, age groups
International Angelman Day: February 15
International Angelman Day (IAD) is an opportunity to raise awareness of Angelman syndrome globally! Two AS parents started IAD in 2012 and engaged 31 Angelman syndrome organisations worldwide to join their efforts.
Sleep in Angelman & Dup15q Syndromes
Explore the differences in sleep patterns between Angelman Syndrome and Dup15q. Understand the causes, treatment options, and future research directions for sleep issues in these syndromes.
Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain
Explore how an artificial transcription factor can restore Ube3a expression in an Angelman Syndrome mouse brain. Discover the protein delivery process, tracking, and future challenges.
Ovid: Towards Improved Outcomes in Rare Neurodevelopmental Disorders Via Targeted Treatments
Discover OVID’s innovative approach to improving outcomes in rare neurodevelopmental disorders. Learn about our upcoming trial in Angelman Syndrome and our unique treatment, OV101.
Next Steps for Dup15q/Angelman Syndrome Research
Explore the challenges and future directions in Dup15q and Angelman Syndrome research. Discussing the role of HERC2, limitations of animal models, and the need for broader therapeutic targeting.
Levodopa in Angelman Syndrome: Results of a Multicenter Randomized Controlled Trial
Explore the results of a multicenter randomized controlled trial on the use of Levodopa in Angelman Syndrome. Discover the scientific basis, trial process, and key findings.
Hurdles to be Overcome for a Trial of Oligonucleotide Therapy in Angelman Syndrome
Explore the potential of oligonucleotide therapy in Angelman Syndrome, discussing challenges in mouse behaviour analysis, humanised mouse creation, and docking strategies. Discover the complexities of UBE3A regulation.
Gene Reviews Overview of Dup15q Syndrome, Angelman Syndrome & the Critical Region
Explore an in-depth overview of Dup15q and Angelman Syndrome, genetic disorders linked to chromosome 15, characterized by developmental delays, autism, epilepsy, and more.